How a brain receptor could lead to suicide prevention
People suffering from post-traumatic stress disorder (PTSD) are at a heightened risk of suicide.
According to an article by Live Science, researchers have found a link between suicidal thoughts and certain receptors on the surface of the brain cells of someone suffering from PTSD, in contrast with people without PTSD.
People with PTSD often suffer from severe anxiety, flashbacks, and uncontrollable thoughts surrounding a traumatic event. It’s primarily caused by any event that causes severe fear and stress and is most common in military combat veterans. The most common symptoms of PTSD, according to Live Science, include:
- Re-experiencing: This includes flashbacks, reliving certain events, nightmares, frightening thoughts, sweating and increased heart rate. Re-experiencing can be triggered at any time when a person with PTSD sees or hears something that brings back memories of an event.
- Avoidance: People with PTSD will often avoid bringing up certain things that remind them of a certain event. They may also avoid certain places, events, or situations that may put them at risk of experiencing flashbacks and uncontrollable thoughts and actions.
- Hyperarousal: People with PTSD may be easily startled, experience chronic stress, and the feeling of being “on edge.” Unlike re-experiencing, this symptom isn’t triggered, but rather constant.
Study findings
The study was recently published in Proceedings of the National Academy of Sciences (PNAS), a peer-reviewed multidisciplinary scientific journal. It found that the brain receptor called metabotropic glutamatergic (mGluR5) found in people with PTSD may be further examined for the development of future PTSD drug treatment. Metabotropic glutamatergic plays a functional role in several brain processes, including learning and memory, sleep, and cognitive functioning.
There are currently only two drugs approved by the Food and Drug Administration (FDA) used for treating patients with PTSD. These drugs were initially designed to treat depression and aren’t effective for everyone with PTSD, however. Moreover, patients with PTSD often don’t benefit from the drug for weeks or months.
In the study, researchers scanned the brains of 29 PTSD patients, 29 people who suffered from depression (but didn’t have PTSD), and 29 people who had no diagnosed psychiatric disorder. Participants were asked if they had experienced any suicidal thoughts on the day of the scan. Those who had active suicidal thoughts with actual intent were excluded from the study and given immediate medical help. Those who had more passive suicidal thoughts without any intent were included in the study.
In comparison with healthy individuals without psychiatric disorder, participants with PTSD had higher levels of mGluR5 on the surface of the brain cells in five regions of the brain. Moreover, researchers found a link between the presence of mGluR5 only in people with PTSD, but not in people with depression.
Researchers are hopeful that the information found in this study will lead to effective suicide prevention for people with PTSD. Currently, drugs that directly target mGluR5 exist, but they have yet to be tested for PTSD treatment. Prior studies suggest that such drugs could cause an increase in anxiety among people with PTSD.
These study findings are a positive step for suicide prevention. The Law Offices of Skip Simpson will continue to keep an eye on these developments. We represent the families of those who have died by suicide across the United States. If you lost a loved one to death by suicide, contact us only to discuss your matter and explore your legal options.

Young people across the United States are among the most vulnerable when it comes to suicide risks. In fact, it is the second most common cause of death among youth ages 10-19 – taking more than 85,000 lives from 1975-2016.
According to the Centers for Disease Control and Prevention, the suicide rate in the United States has increased by 33 percent from 1999-2017 and suicide takes an average of 40,000 lives per year. The rate among children and teens, however, is even higher.
We’ve heard the ceaseless debate over whether or not cannabis is safe for adults. With many states legalizing its use for recreational purpose, some adults enjoy the benefits of cannabis-based products in their leisure time.
People who die by suicide don’t always give warnings or show signs of suffering. They can appear healthy to others while concealing emotional pain, mental illness, or a personality disorder. According to
If you know someone who lost a loved one due to suicide, you’re not alone. According to the Centers for Disease Control and Prevention (CDC), there were approximately 47,173 suicides in the United States in 2017.
Knowing what to do when dealing with a family member or someone else considering
You may have seen him on Saturday Night Live, cracking jokes and sporting a jokers’ grin. You may have heard of him in the tabloids after a highly public split with pop sensation Ariana Grande. And, if you are familiar with the trademarks of borderline personality disorder, you aren’t surprised by the whirlwind romance that came to an abrupt end.
Nurses take our lives into their hands daily. Thousands of patients pass through bustling hospitals waiting to address their various ailments with one of the world’s most in-demand professions. Doctors rely on them, clinics and hospitals can’t operate without them. Nurses deserve our appreciation, gratitude, and proper access to mental healthcare to address their own needs.
